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Genotoxicity of jojoba (Simmondsia chinensis) extracts employing a variety of short-term genotoxic bioassays [electronic resource]

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Masrry, A. M

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Language: English Summary language: Arabic Description: p.17-24Other title:

السمية الوراثية لمستخلصات الجوجوبا بتوظيف مجموعة إختبارات سمية وراثية [Added title page title]

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Alexandria science exchange journal, 2013 v. 34 (1) [electronic resource]:

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In: Alexandria Science Exchange Journal 2013.v.34(1)Summary: Several short-term screening bioassays have been developed to detect mutagenic / carcinogenic potentiality of a substances especially that used as a food additive and or as a pharmaceuticals. At last decade jojoba extracts were widely used in cosmetics and in food additive as well • This work was planned to detect the possible genotoxic effect of jojoba (Simmondsia chinensis) extracts, defatted of jojoba seed meal (DJSM), defatted jojoba seed meal extracts (DJSE) and jojoba (JO) as well as the ability of DJSM and DJSE in reducing the body weight and the ability of JO as well as olive oil (00) for reducing blood cholesterol. In order to achieve such a purpose, forty animals of albino mice (Mus musculus 2n=40) were used and divided into eight groups. The doses of treatments were, 3% DJSM; 0.2 mland 0.1 ml DJSE; 0.2 ml JO; 0.1 ml JO; 0.2 ml 00 and 0.05 ml JO + 0.05 ml 00 in combination. Results showed that both 3% of DJSM and (0.2ml; O.lml) DJSE were effective in reducing body weight compared to untreated controL Jojoba seed oil significantly reduced both total cholesterol and low density lipoprotein for all tested doses of JO and 00.

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Several short-term screening bioassays have been developed to detect mutagenic / carcinogenic potentiality of a substances especially that used as a food additive and or as a pharmaceuticals. At last decade jojoba extracts were widely used in cosmetics and in food additive as well • This work was planned to detect the possible genotoxic effect of jojoba (Simmondsia chinensis) extracts, defatted of jojoba seed meal (DJSM), defatted jojoba seed meal extracts (DJSE) and jojoba (JO) as well as the ability of DJSM and DJSE in reducing the body weight and the ability of JO as well as olive oil (00) for reducing blood cholesterol. In order to achieve such a purpose, forty animals of albino mice (Mus musculus 2n=40) were used and divided into eight groups. The doses of treatments were, 3% DJSM; 0.2 mland 0.1 ml DJSE; 0.2 ml JO; 0.1 ml JO; 0.2 ml 00 and 0.05 ml JO + 0.05 ml 00 in combination. Results showed that both 3% of DJSM and (0.2ml; O.lml) DJSE were effective in reducing body weight compared to untreated controL Jojoba seed oil significantly reduced both total cholesterol and low density lipoprotein for all tested doses of JO and 00.

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