Effects of aqueous extract of miswak Salvadora Persica On Histomorphological structure of the uterus in the female rats [electronic resource]

Includes bibliographic reference.

The uterus is a very important reproductive organ for implantation and holding embryos till
labor. Many drugs and medicinal plants affect the uterus, some researchers reported that
Salvadora persica (Miswak) is a phytoestrogen plant as it contains flavonoids and can be
used as a contraceptive drug; however, no available investigations explain the
histomorphological structure of the uterus after Miswak extract administration. Twelve
female albino rats (165.3 ± 3.269 g) were divided equally into two groups. In the control
group, the animals received normal saline daily for 4 weeks. While in the Miswak treated
group, the animals received 900 mg/kg of body weight of the Miswak aqueous extract daily
for the same period. Grossly, at the end of the experiment, our results revealed that the uteri
in the Miswak-treated group had characteristics of low active organs; they were pale with
low weight and high thickness. In contrast to the treated group, the uteri of the control
group had the signs of active organs; they were more vascular, relatively thin and
edematous. Microscopically, in the control group, the uterine lumen was wide and the
mucosa was folded and covered by secretory columnar epithelium. The uterine glands were
more active, and the myometrium was thick. Whereas, in the Miswak-treated group, the
lumen was slit-like, the uterine glands were less active, and the uterine wall had thick
lamina propria and thin myometrium. In conclusion, the oral administration of Miswak
extract reduces the uterus activity. It showed a state of anestrous with a narrow slit-like
lumen and a decrease in glandular activity.

Keywords: Miswak, Uterus, Structure, Rat, Endometrium, Myometrium

Summary in Arabic