Protective and detoxificating effects of selenium nanoparticles and thyme extract on the aflatoxin b1 in rabbits [electronic resource]

Includes bibliographic reference

Nanotechnology's application in biomedicine has piqued the curiosity of all authorities throughout the world.
Different fungus species and aflatoxins were recovered from rabbit feed at significant quantities up to 300 ppb
in this investigation. Selenium nanoparticles (Se-NPs) were generated using a chemical process, described briefly,
and utilized to reduce the harmful effects of aflatoxicosis in rabbits. Biochemical parameters in tissues and sera
of all aflatoxicated rabbits revealed that it caused the development of reactive oxygen species (ROS), an increase
in nitric oxide levels, and malonaldehyde levels. While Total Antioxidant Capacity (TAC) activities are reduced,
additional antioxidants in rabbit homogenate liver tissues will be found. In aflatoxicosis, decreased serum retinol
and a-tocopherol were also found. For aflatoxicated rabbits, oral treatment of SeNPs and thyme restored these
alterations to normal levels. Furthermore, SeNPs and thyme triggered the breakdown of AFB1 residues in liver tissues,
suggesting that SeNPs and thyme can be introduced to animal feeds as antioxidants with good effects on animal health
and mycotoxins removal.
Keywords: Nanotechnology, Se-NPs, Aflatoxicosis, Thyme, Antioxidant, fungi.

Summary in Arabic