Studies on factors affecting haemagglutinating character of rabbit haemorrhagic disease virus [electronic resource].

Includes references.

Rabbit hemorrhagic disease (RHD) is a highly contagious, per acute and acute fatal viral disease of rabbits caused by a haemagglutinating, enveloped virus, with a single stranded RNA genome, belonging to Lago virus of the Caliciviridae. While HA and HI tests are gold standards for detection of RHD virus (RHDV) in liver tissues used for preparation of the inactivated vaccine, disappearance of this phenomenon at chronic stages of the disease directed this study to thoroughly investigate some factors which could affect HA titer in different steps of vaccine preparation. In addition, reverse transcription and polymerase chain reaction (RT-PCR) was used as a sensitive tool_to detect the presence of RHD viral RNA in livers collected from rabbits at chronic stage of infection and, at the same time, negative in HA test.

Summary in Arabic.

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