Biological effect of ginger (Zingiber officinale Roscoe) on diabetic pregnant and lactating rats [electronic resource].

Includes reference.

Biochemical and histological effects of ginger as a hypoglycemic agent in diabetic albino pregnant rats were investigated. Water extract of ginger was analyzed for phenolic acid determination by HPLC. Ginger essential oil was also analyzed for its volatile components using GC-MS. A total of 35 pregnant albino rats were divided into 7 groups. Group 1 normal healthy control. Group 2 diabetic control which injected with Streptozotocin (STZ) (50mg/kg b.w.) to induce diabetes. Group 3 diabetic rats induced 2gm ginger powder rhizomes/100g diet. Group 4 diabetic rats injected with 3 ml water extract of ginger. Group 5 diabetic rats injected with 0.3 ml essential ginger oil. Group 6 diabetic rats injected with 0.3 ml commercial ginger oil. Group 7 diabitic rats injected with 80mg dimecron drug. Glucose, prolactin, lipids profile as well as kidney and liver function were determined in serum. The result showed that ginger water extract had several phenolic compounds. The main of compounds were sakaruntin, lutolin, rutin, querecetrin and hyperosaid, these were naturally. GC-MS identified 61 compounds in the essential oil of ginger, of which the major compounds were sesquiterpene, geraniol and farnosen. The results also showed that the ginger in forms of powder, water extract or essential oil significantly (P<0.05) reduced glucose, total lipids, triglycerides, total cholesterol, creatinine, urea and uric acid contents as well as the activity of transaminase (GPT and GOT), alkaline phosphates (ALP) in blood of diabetic pregnant albino rats. However, an increase in total protein and albumin/globulin ratio were found compared with the control under the same conditions.

Summary in Arabic.

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