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Antioxidant, hepatorenal and mutagenic effects of butylated hydroxytoluene [electronic resource].

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Atta, A. H

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Language: English Summary language: Arabic Description: p.101-113Other title:

تاثير البوتيلاتيد هيدوكسيتولوين المضاد للأكسدة والواقى للكبد والكليتين والمطفر [Added title page title]

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Veterinary medical journal, 2007 v.55 (1) [electronic resource].

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In: Veterinary Medical Journal 2007.v.55(1)Summary: The antioxidants, biochemical, and mutagenic effects of butylated hydroxytoluene (BHT) in doses of 3 and 30 mg/kg b.wt. were studied in normal and CCl4-intoxicated rats. The oral LD₅₀ of BHT in rats was 1740 mg/kg b.wt. No significant changes of almost all of the studied serum and tissue parameters including bone marrow cells compared to the control groups indicating the safety of this compound. CCI4- intoxicated animals showed significant elevations in serum alanine aminotransferases (ALT), aspartate aminotransfe rases (AST) and alkaline phosphatase (AP) activities. serum bilirubin, cholesterol, creatinine, urea and tissue lipid peroxides (LP) concentrations.

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The antioxidants, biochemical, and mutagenic effects of butylated hydroxytoluene (BHT) in doses of 3 and 30 mg/kg b.wt. were studied in normal and CCl4-intoxicated rats. The oral LD₅₀ of BHT in rats was 1740 mg/kg b.wt. No significant changes of almost all of the studied serum and tissue parameters including bone marrow cells compared to the control groups indicating the safety of this compound. CCI4- intoxicated animals showed significant elevations in serum alanine aminotransferases (ALT), aspartate aminotransfe rases (AST) and alkaline phosphatase (AP) activities. serum bilirubin, cholesterol, creatinine, urea and tissue lipid peroxides (LP) concentrations.

Summary in arabic.

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