Biological and histopathological studies on some herbs mixture in obese rats [electronic resource].

Includes references.

The effects of herbs mixture at different levels of mixture components (Thymus, Fennel and Phyllanthus on some biological and histological factors of hyperlipidemic obese rats were studied. Thirty adult female rats were distributed into five groups, the first one was kept as negative control, while the other four groups were fed on high fat diet for induction of obesity. One of these groups was kept as positive control while the left 4 groups were given daily by 20% mixture of Thymus, Fennel and Phyllanthus at 10,5, 5% mixture, 5,10,5% mixture and 5, 5, 10% mixture for 4 weeks. Results showed that body weight gain was markedly lower especially in the mixture of Thymus, Fennel and Phy/lanthus (5, 5 and 1 0%) compared to high fat diet control group. Also, their mixture at 5,5 and 10% lowered concentrations of total cholesterol, triglycerides, LDL-c, VLDL-c and decreased activity of AST and ALT enzymes. Furthermore, all mixture caused significant increase in HOL-e and T3 hormone concentrations except mixture (1) Thymus, Fennel and Phyllanthus at 10,5 and 5%. Histopathological examination showed amelioration of histopathological lesions seen in liver of obese rats received the mixture of herbs at different levels. This study recommends that intake of the mixture of Thymus, Fennel and Phy/lanthus especially at 5,5 and10% respectivelly because it may be useful for treating obesity.

Summary in Arabic.

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