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The effect of freeze-drying on the keeping quality of anti-tetanic serum [electronic resource].

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Kamal, Fayka

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Language: English Summary language: Arabic Description: p.1373-1381Other title:

دراسات على تأثير التجفيد بالتبريد على الجودة النوعية للمصل المضاد للتيتانوس [Added title page title]

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Egyptian journal of agricultural research, 2002 v. 80 (3) [electronic resource].

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In: Egyptian Journal of Agricultural Research 2002.v.80(3)Summary: The purpose of this work is to obtain lyophilized preparation of tetanus antitoxin, and to study the effect of freeze-drying on the keeping quality of the lyophilized products. Six of antitetanic serum (ATS) products were prepared. These products were: liquid ATS with phenol 0.5%, lyophilized ATS with phenol 0.5%, lyophilized antitoxin immunoglobulin (ATI) with phenol 0.5%, liquid ATS with sodium azide 0.2%, lyophilized ATS with sodium azide 0.2%, lyophilized ATI with 0.2% sodium azide. Saccharose 1% and glycine 2% were used as stabilizer during lyo- philized process. Sterility, safety and potency tests were applied for evaluation of different prepared lyophilized products. The results showed that the lyophilized products were easy reconstituted with distilled water. The products were prepared from ATS with sodium azide 0.2%, ATS with phenol 0.5% and their concentrated antitoxin immunoglobulin (ATI) were bacteriology, mycoplasma and fungal sterile, potent and safe for injection.

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The purpose of this work is to obtain lyophilized preparation of tetanus antitoxin, and to study the effect of freeze-drying on the keeping quality of the lyophilized products. Six of antitetanic serum (ATS) products were prepared. These products were: liquid ATS with phenol 0.5%, lyophilized ATS with phenol 0.5%, lyophilized antitoxin immunoglobulin (ATI) with phenol 0.5%, liquid ATS with sodium azide 0.2%, lyophilized ATS with sodium azide 0.2%, lyophilized ATI with 0.2% sodium azide. Saccharose 1% and glycine 2% were used as stabilizer during lyo- philized process. Sterility, safety and potency tests were applied for evaluation of different prepared lyophilized products. The results showed that the lyophilized products were easy reconstituted with distilled water. The products were prepared from ATS with sodium azide 0.2%, ATS with phenol 0.5% and their concentrated antitoxin immunoglobulin (ATI) were bacteriology, mycoplasma and fungal sterile, potent and safe for injection.

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