Clinicopathological study on fluoride toxicosis and aluminum sulf rateration-supplement in chickens [electronic resource].

Includes references.

The present study was perfonned to investigate the clinicopathological changes associated with sodium fluoride toxicity and aluminum sulphate ration supplement in Balady chickens. One hundred and fifty, one day old Balady chickens were divided into six equal groups. Gp.I was the control. Diet of gps. 2&3 was supplemented with 800 and 1600 ppm sodium fluoride respectively , the ration of gpo 4 was supplemented with 640 ppm aluminum sulphate. The ration of gpo 5 was supplemented with 800 ppm sodium fluoride and 640 ppm aluminum sulphate ,while that of gpo 6 was supplemented with 1600 ppm sodium fluoride together with 1280 ppm aluminum sulphate. Clinically the chickens showed anorexia, poor growth with yellowish-brown diarrhea and toe defonnation which led to stiffness and lameness with high mortality. Gps. 2-6, showed macrocytic hypochromic anemia with decreased thrombocytic count and increased clotting time. Biochemical analysis, revealed hepatic damage (increased activity of liver enzymes ALT, AST and ALP with decreased total protein, albumin and globulin levels) and disturbed renal function (increased uric acid and creatinine, decreased calcium, magnesium and non significant change in inorganic phosphorus). Pathological results confinned the biochemical results which revealed toxic effect of sodium fluoride and aluminum sulphate on the liver and kidneys.

Summary in Arabic.

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