Immuno-Potentiator effect of rapeseed or soybean oil with foot and mouth disease vaccine in calves [electronic resource]
Language: English Summary language: Arabic Description: p. 92–102Uniform titles:- Journal of applied veterinary sciences, 2020 v.5 (3)
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Main | ART JAVS V5 NO3 11 (Browse shelf(Opens below)) | Available |
Includes bibliographic reference
One of the effective recommendation for control of Foot and Mouth disease virus is the proper vaccination by a highly potent vaccine.
Such a vaccine should be specific to the circulated field serotype of foot and mouth disease virus inducing rapid, highly protective
immunity with a long duration. This research is concerned with using plant extracted oil adjuvants prepared from rapeseed oil mixed
with or without Ginseng extracts and from Soybean oil as well with or without Ginseng extracts. Some humoral and cellular immune responses
were compared using the different plant-extracted oils and the mineral-based adjuvant called Montanide oil ISA 206 after one dose vaccination
of the prepared vaccines at different interval times post vaccinations. Lymphocyte blastogenesis, Interleukin-6, and Interleukin-12 showed higher
expression in calves vaccinated by FMDV serotypes (O pan Asia, A Iran O5, and SAT2 / EGY/2012) with plant extract oil containing Ginseng extract
comparable to that of plant extracts without Ginseng and Montanide oil ISA 206 adjuvants vaccines. It was found that FMD vaccine adjuvant with
ginseng either with rapeseed or Soybean showed a higher post vaccinal cellular immune response than that without ginseng or ISA 206 alone.
Estimation of the humoral immune response of vaccinated calves revealed that antibody against FMD virus serotypes O pan Asia, A Iran O5
and SAT2 / EGY/2012 by SNT and ELISA assay induced by the inactivated FMD adjuvant with rapeseed oil and ginseng vaccine and the inactivated
FMD adjuvant with soybean oil and ginseng vaccine were higher than those induced by inactivated FMD adjuvant with Montanide oils 206.
In contrast, the obtained antibody levels by the inactivated FMD adjuvant with rapeseed oil vaccine and inactivated FMD adjuvant with soybean
oil vaccine was lower than those induced by inactivated FMD adjuvant with Montanide oils 206. So, it could be concluded that the use of plant
origin oil adjuvant as rapeseed and soybean oil is considered a beneficial and alternative adjuvant to the imported mineral oil as it is
much cheaper and induce better post vaccinal immune responses especially when mixed with ginseng extract.
Summary in Arabic
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