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Effect of Diniconazole on metabolic profile of albino rats [electronic resource].

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Zidan, Z. A

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Language: English Summary language: Arabic Description: p.913-933Other title:

تأثير الدينيكونازول علي نظام التمثيل في الفئران البيضاء [Added title page title]

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Arab universities journal of agricultural sciences, 2003 v. 11 (2) [electronic resource].

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In: Arab Universities Journal of Agricultural Science 2003.v.11(2)Summary: This study was conducted to evaluate the subchronic toxicity ofdinicooazole fungicide in male albino rats. Diniconazole caused a significant decrease in the activity of aspartate aminotransferase (AS1) on the 90th day oftreatment, while, the alanine aminotransferase (ALT) did not alter significantly throughout the experiment. Plasma alkaline phosphatase (ALP) activity showed a marked elevation after treabnent with diniconazole, .after the recovery period the values returned to the normal levels. The creatine phosphokinase (CPK) decreased significantly after 15 days, but increased·after 30 days from treatment and approached to normal values during the recovery period. Diniconazole treatments did not alter significantly urea, uric acid, total protein, albumin and magnesiwn levels while creantinine and glucose levels declined in treated rats after 90 and 45 days, respectively. In addition, plasma total lipids, total cholesterol and triglycerides levels were varied throughout the experiment Treatments with diniconazole for 90 days produced a slight toxic effect on parathormone level and calcium profile as well as the inorganic phosphorus level. Diniconazole induced a significant increase of body and brain weights while, the weights of liver, lung, heart. kidney, spleen and testes did not change throughout the experiment A moderate damage in kidney tissues in diniconazole treated rats was also observed

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This study was conducted to evaluate the subchronic toxicity ofdinicooazole fungicide in male albino rats. Diniconazole caused a significant decrease in the activity of aspartate aminotransferase (AS1) on the 90th day oftreatment, while, the alanine aminotransferase (ALT) did not alter significantly throughout the experiment. Plasma alkaline phosphatase (ALP) activity showed a marked elevation after treabnent with diniconazole, .after the recovery period the values returned to the normal levels. The creatine phosphokinase (CPK) decreased significantly after 15 days, but increased·after 30 days from treatment and approached to normal values during the recovery period. Diniconazole treatments did not alter significantly urea, uric acid, total protein, albumin and magnesiwn levels while creantinine and glucose levels declined in treated rats after 90 and 45 days, respectively. In addition, plasma total lipids, total cholesterol and triglycerides levels were varied throughout the experiment Treatments with diniconazole for 90 days produced a slight toxic effect on parathormone level and calcium profile as well as the inorganic phosphorus level. Diniconazole induced a significant increase of body and brain weights while, the weights of liver, lung, heart. kidney, spleen and testes did not change throughout the experiment A moderate damage in kidney tissues in diniconazole treated rats was also observed

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