Experimental studies on the effect of neomycin B on rotavirus replication
Salama, Ali A.
Experimental studies on the effect of neomycin B on rotavirus replication [electronic resource]. دراسات تجريبية على تأثير النيوميسين-بى على تكاثر فيروس الروتا. - p.137-144.
Includes references.
Bovine Rotavirus (BRV) is a major cause of acute gastroenteritis in newborn calves throughout the world causing economic losses to beef and dairy industries. Neomycin B, an aminoglycoside antibiotic has been shown to inhibit rotavirus replication in-vitro. The current study was carried out to study the availability of neomycin B as preventive and chemotherapeutic mean for rotavirus infection, It was conducted by following up the replication of virus inside the infected and infected treated mice. Moreover the shedding of virus by infected and infected treated mice was determined by immunofluorescence (IF). The group of mice inoculated with BRV and simultaneously treated with neomycin had significant reductions in virus shedding by 1.43 and 1.7 logs at first day and 5th day post BRV inoculation respectively. It was revealed that neomycin has an interfering effect on rotavirus replication in-vivo (in mice), when the drug administered before, during and after viral infection. Further studies for field applications of neomycin as therapeutic measure for Bovine Rotavirus infection in newborn calves especially in calves born from non vaccinated animals or born with low titer of antibodies need to be done.
Summary in Arabic.
Rotaviruses.
Viruses--Reproduction.
Neomycin.
Aminoglycosides--Therapeutic use.
Calves--Vaccination.
Experimental studies on the effect of neomycin B on rotavirus replication [electronic resource]. دراسات تجريبية على تأثير النيوميسين-بى على تكاثر فيروس الروتا. - p.137-144.
Includes references.
Bovine Rotavirus (BRV) is a major cause of acute gastroenteritis in newborn calves throughout the world causing economic losses to beef and dairy industries. Neomycin B, an aminoglycoside antibiotic has been shown to inhibit rotavirus replication in-vitro. The current study was carried out to study the availability of neomycin B as preventive and chemotherapeutic mean for rotavirus infection, It was conducted by following up the replication of virus inside the infected and infected treated mice. Moreover the shedding of virus by infected and infected treated mice was determined by immunofluorescence (IF). The group of mice inoculated with BRV and simultaneously treated with neomycin had significant reductions in virus shedding by 1.43 and 1.7 logs at first day and 5th day post BRV inoculation respectively. It was revealed that neomycin has an interfering effect on rotavirus replication in-vivo (in mice), when the drug administered before, during and after viral infection. Further studies for field applications of neomycin as therapeutic measure for Bovine Rotavirus infection in newborn calves especially in calves born from non vaccinated animals or born with low titer of antibodies need to be done.
Summary in Arabic.
Rotaviruses.
Viruses--Reproduction.
Neomycin.
Aminoglycosides--Therapeutic use.
Calves--Vaccination.