Pharmacokinetic evaluation of cefotaxime after intramuscular administration in chickens
Mohmad, M. A.
Pharmacokinetic evaluation of cefotaxime after intramuscular administration in chickens [electronic resource]. تقييم الحركة الدوائية للسيفوتاكسيم بعد الحقن العضلى فى الدجاج. - p.155-159.
Includes references.
Phannacokinetics of cefotaxime was investigated in clinically healthy chickens following single intramuscular injection of three doses (5, 10 and 20 mglkg.bwt.). An increase in concentration of the drug was found with increasing dose at all the sampling times in each subject. The peak serum concentrations (Cmax) of cefotaxime was 4.5, 8.0 and 21.60Jlglml at maximum time at which the drug reach maximum concentration (tmax) of 28, 29 and 30 minutes, respectively. The serum concentrations was decreased with elimination half lives (lO.5e) of 0.72 ,0.70 and 0.71 hours and The area under serum drug concentration (AUCo-oo) was 7.09, 12.32 and 32.58 Jlg.mP.h for the three doses, respectively.
Summary in Arabic.
Pharmacokinetics.
Cefotaxime--Pharmacokinetics
Escherichia coli infections.
Pharmacokinetic evaluation of cefotaxime after intramuscular administration in chickens [electronic resource]. تقييم الحركة الدوائية للسيفوتاكسيم بعد الحقن العضلى فى الدجاج. - p.155-159.
Includes references.
Phannacokinetics of cefotaxime was investigated in clinically healthy chickens following single intramuscular injection of three doses (5, 10 and 20 mglkg.bwt.). An increase in concentration of the drug was found with increasing dose at all the sampling times in each subject. The peak serum concentrations (Cmax) of cefotaxime was 4.5, 8.0 and 21.60Jlglml at maximum time at which the drug reach maximum concentration (tmax) of 28, 29 and 30 minutes, respectively. The serum concentrations was decreased with elimination half lives (lO.5e) of 0.72 ,0.70 and 0.71 hours and The area under serum drug concentration (AUCo-oo) was 7.09, 12.32 and 32.58 Jlg.mP.h for the three doses, respectively.
Summary in Arabic.
Pharmacokinetics.
Cefotaxime--Pharmacokinetics
Escherichia coli infections.