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Pharmacokinetic evaluation of cefotaxime after intramuscular administration in chickens [electronic resource].

By:

Mohmad, M. A

Contributor(s):

Gehan, NA

Language: engbara Description: p.155-159Other title:

تقييم الحركة الدوائية للسيفوتاكسيم بعد الحقن العضلى فى الدجاج.‪ [Added title page title]

Uniform titles:

Zagazig veterinary journal, 2011 v. 39 (3) [electronic resource].

Subject(s):

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In: Zagazig Veterinary Journal 2011.v.39(3)Summary: Phannacokinetics of cefotaxime was investigated in clinically healthy chickens following single intramuscular injection of three doses (5, 10 and 20 mglkg.bwt.). An increase in concentration of the drug was found with increasing dose at all the sampling times in each subject. The peak serum concentrations (Cmax) of cefotaxime was 4.5, 8.0 and 21.60Jlglml at maximum time at which the drug reach maximum concentration (tmax) of 28, 29 and 30 minutes, respectively. The serum concentrations was decreased with elimination half lives (lO.5e) of 0.72 ,0.70 and 0.71 hours and The area under serum drug concentration (AUCo-oo) was 7.09, 12.32 and 32.58 Jlg.mP.h for the three doses, respectively.

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Phannacokinetics of cefotaxime was investigated in clinically healthy chickens following single intramuscular injection of three doses (5, 10 and 20 mglkg.bwt.). An increase in concentration of the drug was found with increasing dose at all the sampling times in each subject. The peak serum concentrations (Cmax) of cefotaxime was 4.5, 8.0 and 21.60Jlglml at maximum time at which the drug reach maximum concentration (tmax) of 28, 29 and 30 minutes, respectively. The serum concentrations was decreased with elimination half lives (lO.5e) of 0.72 ,0.70 and 0.71 hours and The area under serum drug concentration (AUCo-oo) was 7.09, 12.32 and 32.58 Jlg.mP.h for the three doses, respectively.

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