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Comparative studies on the immune response elicited in chickens vaccinated with recombinant avian influenza-fowl pox vaccines as a primary vaccine or prime-boost scheme [electronic resource].

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Omar, Lamiaa M

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Language: English Summary language: Arabic Description: P. 171-180Other title:

دراسات مقارنة بين رد الفعل المناعى للدجاج المحصن لكل من لقاح الأنفلونزا المحمل على فيروس جدرى الطيور و لقاح الأنفلونزا المثبط [Added title page title]

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Zagazig veterinary journal, 2011 v. 39 (2) [electronic resource].

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In: Zagazig Veterinary Journal 2011.v.39(2)Summary: Comparative immunological studies on different types of Live recombinant Fowl Pox virus containing the avian influenza H5 hemagglutinin (RA) gene (rFP-AI-H5) from several strains were done to evaluate their efficacies. Susceptible SPF chickens were vaccinated with the rFP-AIH5/ Scotland and rFP-AI-H5/Irland vaccines as primary or prime-boost vaccination with killed H5N2 vaccine to study the immune response against them through monitoring protection % against local circulating highly pathogenic avian influenza (HPAI) H5N1 strain 28 days post-vaccination. All vaccinated chickens with one or double doses of live recombinant vaccines and challenged with HPAIV succumbed to disease, while those vaccinated with killed vaccine or recombinant vaccines as prime-boosted by killed AI vaccine were protected from severe clinical signs and death. Both rFPAI- H5/Scotland and rFP-AI-H5/Irland vaccines induced poor protection % when used as one dose (17.7% and 37.5%) or as two doses (23.5% and 47.1%) against HPAIV.

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Comparative immunological studies on different types of Live recombinant Fowl Pox virus containing the avian influenza H5 hemagglutinin (RA) gene (rFP-AI-H5) from several strains were done to evaluate their efficacies. Susceptible SPF chickens were vaccinated with the rFP-AIH5/ Scotland and rFP-AI-H5/Irland vaccines as primary or prime-boost vaccination with killed H5N2 vaccine to study the immune response against them through monitoring protection % against local circulating highly pathogenic avian influenza (HPAI) H5N1 strain 28 days post-vaccination. All vaccinated chickens with one or double doses of live recombinant vaccines and challenged with HPAIV succumbed to disease, while those vaccinated with killed vaccine or recombinant vaccines as prime-boosted by killed AI vaccine were protected from severe clinical signs and death. Both rFPAI- H5/Scotland and rFP-AI-H5/Irland vaccines induced poor protection % when used as one dose (17.7% and 37.5%) or as two doses (23.5% and 47.1%) against HPAIV.

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