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Effect of ascorbic acid and ribavirin substances on Rift Valley Fever virus [electronic resource].

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Shalkamy, Eman M

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Language: English Summary language: Arabic Description: p.63-72Other title:

تأثير حمض الأسكوربيك والربيافيرين على فيروس حمى الوادى المتصدع

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Beni-Suef veterinary medical journal, 2001 v. 11 (1) [electronic resource].

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In: Beni-Suef Veterinary Medical Journal 2001.v. 11(1)Summary: The present work aimed to study the potentiality of two antiviral agents; ascorbic acid and ribavirin on Rift Valley Fever virus in vivo and vitro. The study was done on BHK-21 cell line and swiss albino mice. The results revealed that the optimal concentration of ascorbic acid which gave the highest percentage of protection against RVF virus inoculation in mice was 5 ug which were detected on 3rd and 7th day post injection then declined rapidly on the 10 Th day due to the rapid excretion of the drug.All concentrations of ascorbic acid (A. A.) used to study the CPE in T.c. revealed complete inhibition of the virus.Concerning ribavirin (R.n.) the best concentration injected in mice and showed the highest protection was 0.16ug and that was. clear on the 3rd and 7th day post treatment. Complete suppresion of the virus was also detected on infected BHK cells which was treated with various concentration of ribavirin drug.

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The present work aimed to study the potentiality of two antiviral agents; ascorbic acid and ribavirin on Rift Valley Fever virus in vivo and vitro. The study was done on BHK-21 cell line and swiss albino mice. The results revealed that the optimal concentration of ascorbic acid which gave the highest percentage of protection against RVF virus inoculation in mice was 5 ug which were detected on 3rd and 7th day post injection then declined rapidly on the 10 Th day due to the rapid excretion of the drug.All concentrations of ascorbic acid (A. A.) used to study the CPE in T.c. revealed complete inhibition of the virus.Concerning ribavirin (R.n.) the best concentration injected in mice and showed the highest protection was 0.16ug and that was. clear on the 3rd and 7th day post treatment. Complete suppresion of the virus was also detected on infected BHK cells which was treated with various concentration of ribavirin drug.

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