Amelioration of cisplatin-induced nephrotoxicity in dogs by vitamin C and fish oil [electronic resource].

Includes references.

In a trial to study the possible prophylactic role of vitamin C and fish oil against the cisplatin induced nephrotoxicity in dogs. Forty two dogs were used. classified into seven equal groups, (I) served as control injected with physiological saline, (II) injected witll a single dose of vitamin C (200 mg/kg b.wt. i.v.). (III) injected with a single dose of fish oil (2 ml/kg b.wt. i.v.). (IV) injected with a single dose of cisplatin (5 mg/kg b.wt. i.v.) (V) injected with a single dose of cisplatin plus vitamin C. (VI) injected with a single dose of cisplatin pluS fish oil and (VII) injected with a single dose of cisplatin pluS both vitamin C and fish oil. Dogs were sacrificed 7-days post treatment. Blood samples and kidney tissues were taken for biochemical investigations. From the obtained results, significant decreases were reported in the renal enzyme activities of catalase (CAT). glutathione peroXidase (GpxJ and superoxide disn,utase (SOD) and reduced glutathione in cisplatin-injected dogs. In the opposite. plasma, and kidney malondialdehyde (MDA). urea (BUN) and creatinine were significantly increased.

Summary in Arabic.

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