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Dlinicopathological studies on the effect of antifungal drugs in rabbits [electronic resource].

By:

Badr, Mohamed O.T

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Language: English Summary language: Arabic Description: p.108-119Other title:

دراسات باثولوجية اكلينكية علي تأثير الأدوية المضادة للفطريات في الارانب [Added title page title]

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Zagazig veterinary journal, 2010 v. 38 (3) [electronic resource].

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In: Zagazig Veterinary Journal 2010.v.38(3)Summary: The present study was performed to evaluate the side-effucts of itraconazole and nystatin, besides the ameliorating effect of propolis against the side-effects of such drugs using the clinicopathological changes. Sixty healthy New Zealand male rabbits,(one month old and 500 grn body weight) were divided into 6 equal groups. Gp.l,was the control. Gps.2-6 were orally given itraconazole, nystatin, propolis ,combination of the half therapeutic dose of itraconazole and propolis and combination of the half therapeutic dose from nystatin and propolis,respectively daily for one month using stomach tube, then treatments were stopped for 7 days. Blood samples were collected after 15 (1 st period) and 30 (2nd period)days from start of experiment and after 7 days (3rd period)after the end oftreatment. Gp. 2 showed increased serum ALT,AST and ALP activities ,besides the total, direct, indirect bilirubin, total lipids, cholesterol, triglycerides, urea, creatinine, calcium, inorganic phosphorus and potassium levels in addition to decreased serum albumin, globulin and sodium levels. Hemolytic anemia, neutropenia and eosinophilia were seen .Those changes were ameliorated in gp.5. Gp.4 showed improvement of the previous parameters. Gps.3 & 4showed no changes when compared with the control. The side effects produced by antifungal drugs, need more than 7 days to regain the normal level.

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The present study was performed to evaluate the side-effucts of itraconazole and nystatin, besides the ameliorating effect of propolis against the side-effects of such drugs using the clinicopathological changes. Sixty healthy New Zealand male rabbits,(one month old and 500 grn body weight) were divided into 6 equal groups. Gp.l,was the control. Gps.2-6 were orally given itraconazole, nystatin, propolis ,combination of the half therapeutic dose of itraconazole and propolis and combination of the half therapeutic dose from nystatin and propolis,respectively daily for one month using stomach tube, then treatments were stopped for 7 days. Blood samples were collected after 15 (1 st period) and 30 (2nd period)days from start of experiment and after 7 days (3rd period)after the end oftreatment. Gp. 2 showed increased serum ALT,AST and ALP activities ,besides the total, direct, indirect bilirubin, total lipids, cholesterol, triglycerides, urea, creatinine, calcium, inorganic phosphorus and potassium levels in addition to decreased serum albumin, globulin and sodium levels. Hemolytic anemia, neutropenia and eosinophilia were seen .Those changes were ameliorated in gp.5. Gp.4 showed improvement of the previous parameters. Gps.3 & 4showed no changes when compared with the control. The side effects produced by antifungal drugs, need more than 7 days to regain the normal level.

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