Antimutagenic activity of bee pollen and propolis water extracts against cisplatin-induced chromosomal abnormalities in bone marrow cells of mice [electronic resource].

Includes references.

The protective activity of Bee-collected pollen (BPE) and watersoluble derivative of propolis (WSDPE) aqueous extracts was studied on cisplatin (CDDP) induced genotoxicity in male albino mice (Mus mascullus). The treatment of mice with Bee-collected pollen and propolis extracts at doses 140 and 8.4 mg/kg body weight/day, respectively for 14 days synergistically with the intraperitoneal administration of cisplatin at dose of 2.8 mglkg b.wt Јexhibited significant chemoprotective activity. Genotoxicity and cytotoxicity were evaluated by the bone marrow chromosomal aberration assay and mitotic index, respectively. The animals of positive control group (CDDP alone) showed a significant increase in genotoxicity. WSDPE and BPE, alone did not significantly induce chromosomal aberrations confirming their non-mutagenic effects. While, the animals in groups five and six (G5 and G6), that were injected i.p. with CDDP alone for one week and then for the next 14 days these animals were given WSDPE and BPE through oral intubation in synergistic with i.p. injection of CDDP, exhibited a significant decrease in cytogenetic damages induced by CDDP in bone marrow cells.

Summary in Arabic.

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