Efficacy and safety of ivermectin administered orally to infected rabbits with mange [electronic resource].

Includes references.

The purpose of this study was to evaluate the efficacy of oral formulation containing ivermectin for treatment of sarcoptic mange in rabbits . Twenty mixed-breed rabbits with a mean age of 9 months from a rabbit husbandry were enrolled in the study. Rabbits were treated with ivermectin at 400 μg /kg. body weight, one oral dose . No other treatment or environmental decontamination was performed during the trial .On Days 0, 7,14 and 28 after dosing all rabbits were examined, and epidermal debris was collected for microscopic examination. Clinical signs had subsided by Day 7 in 4/5 rabbits and almost no signs of recurrence were apparent in the following weeks. All epidermal samples were negative by Day 28. No adverse reactions were observed. Our investigations on serum biochemical parameters showed a significant differences than normal ranges, after 4 weeks post administration of the drug .Under the conditions of our study, oral formulation of ivermectin was a practical and well-tolerated means of treatment for mange in rabbits.

Summary in Arabic.

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