Using of cells and their organelles as tools in study the toxic effect of deltamethrin and profenofos [electronic resource].

Includes reference.

The purpose of the present study is to investigation the potential toxic effects of deltamethrin and profenofos (1/10 and 1120 of LD₅₀) that have different active ingredient on blood picture and ultrastructure changes on cell's contents of liver and Kidney as tools in study the toxic effects on albino rats. Obtained data indicated that deltamethrin and profenofos at 1110 and 1/20 of LO₅₀ caused increase in WBC's count after nine months. While the two formulations caused significant decrease in RaG's count after same time, similar effects were noticed on Hemoglobin value, and platelets count of treated rat. No sharp variations were noticed between different two formulations and different doses in cellular organelles in liver cells treated rats. The results so far obtained indicated hista-and cytopathological alteration by electron microscope due to the effect of compounds when compared with control ones, some sections poorly differentiated hepatocellular showing marked polymorphis of the nuclei, irregularity of the chromatin and prominent nucleoli in treated rats with deltamethrin when compared with control. Also, in treated with prolenofos showed numbers of nuclei and their content in different section by many powers of vision, results show differences and all treatments induce genotoxicity.

Summary in Arabic.

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