Interaction of semduramicin and salinomycin with ciprofloxacin, erythromycin and sulphadimethoxin-trimethoprim [electronic resource].

Includes references.

Interactions between each of the iOnOphores semduramicin (Aviax), salinomycin (Sacox) with each of ciprofloxacin, eryhtromycin and sulphadlmethoxin-trimethoprim were investigated. The ionophore under investigation was fed for 28 days to 48-hours baby chicks prior to 7 days medication with each of the previously cited antimicrobial and/or ionophores at recommended levels. Groups of birds contained negative non-medicated controls, ionophore alone, antimicrobial alone and ionophore plus other antimicrobiaL Different diagnostic criteria were used. Clinical and toxic signs were detected in groups fed semduramicin and medicated with ciproflaxacin and in groups fed salinomycin and treated with erythromycin. However, spasmodic clonic spasms and incoordination disappeared few hours post appearance. Water consumption was significantly dropped in groups fed semduramicin or salinomycin and supplied with sulfonamides and in groups fed salinomycin and supplied with erythromycin. Reductions in body weight were significantly seen in groups fed salinomycin and supplied with sulphonamides.

Summary in Arabic.

1